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Infantile spasms: some new theoretical aspects.

Abstract
Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, in an indirect way, a partial explanation of the biochemical events in this syndrome; most of these actions are well documented in animal experiments. Some anticonvulsants are also effective in treating infantile spasms, and modern research has explained many actions of these agents as well. The principal mechanism causing retardation in most children is unknown. Some future aspects of the research are reviewed.
AuthorsR Riikonen
JournalEpilepsia (Epilepsia) Vol. 24 Issue 2 Pg. 159-68 (Apr 1983) ISSN: 0013-9580 [Print] United States
PMID6299720 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenal Cortex Hormones
  • Anticonvulsants
  • Adrenocorticotropic Hormone
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Adrenocorticotropic Hormone (therapeutic use)
  • Anticonvulsants (therapeutic use)
  • Brain (metabolism)
  • Humans
  • Infant
  • Infant, Newborn
  • Intellectual Disability (etiology)
  • Spasms, Infantile (complications, drug therapy, etiology)

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