Clinical experience with cefotaxime in obstetric and gynecologic infections.

Abstract

Infections in the upper genital tract continue to be one of the leading causes of serious morbidity for obstetric and gynecologic patients. The polymicrobial, mixed aerobic and anaerobic isolates recovered from women with such infections demand broad-spectrum antimicrobial activity. In the past, combination therapy has been given in order to attain this coverage. In a multicenter open study, cefotaxime was used for treatment of endomyometritis after cesarean section, pelvic cellulitis after hysterectomy, and acute pelvic inflammatory disease. The drug effected a clinical cure in 93% of 104 women. In a randomized comparative study conducted at one center, cefotaxime cured 97% of 36 cases of post-cesarean section endomyometritis; clindamyclin plus gentamicin cured 94% of 18 cases of the same infection. There was no evidence of significant alteration in hematopoietic, hepatic, or renal function with either regimen. Cefotaxime appears to be a safe, extremely effective antimicrobial drug that is ideally suited for single-agent treatment of serious soft-tissue pelvic infections in obstetric or gynecologic patients.

• Authors: D L Hemsell, F G Cunningham, C M Nolan, T T Miller
• Journal: Reviews of infectious diseases (Rev Infect Dis) 1982 Sep-Oct Vol. 4 Suppl Pg. S432-8 ISSN: 0162-0886 [Print] United States
• PMID: 6294795 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Gentamicins
• Clindamycin
• Cefotaxime

Topics

• Adolescent
• Adult
• Bacterial Infections (drug therapy)
• Cefotaxime (therapeutic use)
• Cesarean Section
• Clindamycin (administration & dosage)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Endometritis (drug therapy)
• Female
• Gentamicins (administration & dosage)
• Humans
• Hysterectomy
• Middle Aged
• Parametritis (drug therapy)
• Pelvic Inflammatory Disease (drug therapy)
• Postoperative Complications
• Pregnancy
• Puerperal Infection (drug therapy)