Abstract |
This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. The tumour was found in the autopsy case of a 3-year-old girl with clinical manifestation of intractable diarrhea, hypokalemia, achlorhydria, and with elevated levels of plasma vasoactive intestinal peptide (VIP). Immunoperoxidase staining showed many immunoreactive VIP- containing cells, some somatostatin-and substance P-containing cells on the tumour sections. Ultrastructurally, the tumour cells contained numerous secretory granules that could be divided mainly two types; one is a small cored vesicle (50-150 nm in diameter) and the other large electron dense secretory granule (200-500 nm in diameter). It was suggested that the cells in ganglioneuroblastoma derived from neural crest are closely related to the cells that could differentiate into gut- hormone-producing cells.
|
Authors | S Yagihashi, N Shimoyama, T Morita, T Sato, N Yanaihara |
Journal | Acta pathologica japonica
(Acta Pathol Jpn)
Vol. 32
Issue 5
Pg. 807-14
(Sep 1982)
ISSN: 0001-6632 [Print] Australia |
PMID | 6291317
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Peptides
- Vasoactive Intestinal Peptide
|
Topics |
- Adrenal Gland Neoplasms
(analysis, complications)
- Child, Preschool
- Diarrhea
(etiology)
- Female
- Ganglioneuroma
(analysis, complications)
- Histocytochemistry
- Humans
- Immunoenzyme Techniques
- Microscopy, Electron
- Peptides
(analysis)
- Syndrome
- Vasoactive Intestinal Peptide
(analysis)
- Vipoma
(pathology)
|