Abstract |
Cefotaxim was administered intravenously in a dose of 50 mg/kg body-weight before and immediately after cardiac surgery. The drug's concentrations were measured in serum, myocardium, peri-operative fat, pericardium and skeletal muscle. The highest concentration was found 15 minutes after injection: 32 micrograms/g in pericardium, 22 micrograms/g in myocardium, 17.9 micrograms/g in fat and 12.3 micrograms/g in skeletal muscle. After 2 hours the average concentration in pericardium was 10.7, in myocardium 3.8, in fat 5.4 and in skeletal muscle 2.4 micrograms/g. The corresponding mean serum levels were 237.4 and 33.3 micrograms/ml, respectively. The tissue concentrations were thus high enough to be effective against infections caused by cefotaxim-sensitive organisms. There was primary wound healing in all 16 patients. No other infections, such as pneumonia or urinary infections, occurred.
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Authors | D Adam, E Struck |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 107
Issue 35
Pg. 1314-6
(Sep 03 1982)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Cefotaxim zur perioperativen Kurzzeitprophylaxe bei herzchirurgischen Eingriffen. Konzentrationen im Herzmuskel-, Perikard-, Fett- und Skelettmuskel-Gewebe. |
PMID | 6288337
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adipose Tissue
(analysis)
- Adult
- Aged
- Cardiac Surgical Procedures
- Cefotaxime
(analysis, blood, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Muscles
(analysis)
- Myocardium
(analysis)
- Pericardium
(analysis)
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