Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.

The antiphlogistic activity of meseclazone and its major metabolite, 5-chlorosalicylic acid, have been directly compared to acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in rat paw edema induced by eleven different phlogistic agents. Based on the profile of activity and milligram/kilogram potency displayed by meseclazone, it most closely resembles acetylsalicylic acid and phenylbutazone in its mode of action.
AuthorsR D Sofia
JournalPharmacology (Pharmacology) Vol. 16 Issue 3 Pg. 148-52 ( 1978) ISSN: 0031-7012 [Print] SWITZERLAND
PMID628674 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Isoxazoles
  • Oxazines
  • Salicylates
  • Phenylbutazone
  • Aspirin
  • Hydrocortisone
  • Indomethacin
  • Animals
  • Anti-Inflammatory Agents
  • Aspirin (therapeutic use)
  • Drug Evaluation, Preclinical
  • Edema (drug therapy)
  • Hydrocortisone (therapeutic use)
  • Indomethacin (therapeutic use)
  • Isoxazoles (therapeutic use)
  • Male
  • Oxazines (therapeutic use)
  • Phenylbutazone (therapeutic use)
  • Rats
  • Salicylates (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: