Protective effects of WR-2721 against radiation-induced injury of murine gut, testis, lung, and lung tumor nodules.

Abstract

WR-2721 (S-2-(3 aminopropylamino) ethylphosphorothioic acid) has been investigated for its ability to protect gut, lung, and testis, as well as fibrosarcoma (FSa) tumor nodules, in the lungs of mice from gamma-radiation injury. This compound greatly protected jejunum and testis epithelial cells. FSa micrometastases in the lung were protected to a lesser extent than jejunum and testis. Conversely, WR-2721 was not able to protect the lung against radiation-induced enhancement of tumor metastases formation generated by intravenously injected FSa cells.

• Authors: L Milas, N Hunter, B O Reid
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) 1982 Mar-Apr Vol. 8 Issue 3-4 Pg. 535-8 ISSN: 0360-3016 [Print] United States
• PMID: 6286549 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Organothiophosphorus Compounds
• Radiation-Protective Agents
• Amifostine

Topics

• Amifostine (pharmacology)
• Animals
• Digestive System (cytology, radiation effects)
• Lung (radiation effects)
• Lung Neoplasms (radiotherapy)
• Male
• Mice
• Mice, Inbred C3H
• Neoplasm Metastasis
• Organothiophosphorus Compounds (pharmacology)
• Radiation Injuries, Experimental (prevention & control)
• Radiation-Protective Agents
• Testis (radiation effects)