Unusual intranuclear inclusions in malignant fibrous histiocytoma: presence in primary tumor, metastases, and xenografts.

Abstract

We describe previously unreported intranuclear inclusions in 2 cases of malignant fibrous histiocytoma. The inclusions were found in 2-10% of the tumor cells removed from the patients and in 2-10% of the cells examined in tumor tissue xenotransplanted in nude mice. By stereo electron microscopy the inclusions are closely packed undulating fibrils 18-23 nm in diameter. They are sometimes associated with fibrillary bodies. They closely resemble the inclusions reported in some animals inoculated with serum from patients with non-A non-B hepatitis; however, their nature at present is unknown.

• Authors: T S Tralka, C Yee, T J Triche, J Costa, H P Dienes
• Journal: Ultrastructural pathology (Ultrastruct Pathol) Vol. 3 Issue 2 Pg. 161-7 ( 1982) ISSN: 0191-3123 [Print] England
• PMID: 6285572 (Publication Type: Case Reports, Journal Article)

Chemical References

• Heterochromatin

Topics

• Adult
• Animals
• Cell Nucleus (ultrastructure)
• Heterochromatin (ultrastructure)
• Histiocytoma, Benign Fibrous (pathology, ultrastructure)
• Humans
• Lung Neoplasms (secondary, ultrastructure)
• Male
• Mice
• Microscopy, Electron
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Transplantation
• Soft Tissue Neoplasms (pathology, ultrastructure)
• Transplantation, Heterologous