Reduced nerve blood flow in hexachlorophene neuropathy: relationship to elevated endoneurial fluid pressure.

Abstract

To test the hypothesis that increased endoneurial fluid pressure (EFP) causes a reduction in nerve blood flow (NBF) in the vasa nervorum, we adapted a noninvasive method for measurement of nerve blood flow which was originally developed for measurement of local cerebral blood flow. This technique measures tissue distribution to the radioisotope, 14C-iodoantipyrine, and was used to compare NBF in sciatic nerves of rats with increased EFP induced by feeding them hexachlorophene (HCP), a neurotoxin which causes edema exclusively to the nervous system and confined to the myelin sheath. Elevation of interstitial fluid pressure in peripheral nerves from control values of 2.0 +/- 1.0 cm H2O to over approximately 6 cm H2O was associated with a statistically significant reduction in nerve blood flow from 14.8 +/- 5.9 to 7.8 +/- 2.5 ml/100 g of tissue/minute (min). These results support the hypothesis that increased endoneurial fluid pressure exacerbates the neuropathy by diminishing local blood flow.

• Authors: R R Myers, A P Mizisin, H C Powell, P W Lampert
• Journal: Journal of neuropathology and experimental neurology (J Neuropathol Exp Neurol) Vol. 41 Issue 4 Pg. 391-9 (Jul 1982) ISSN: 0022-3069 [Print] England
• PMID: 6283035 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hexachlorophene

Topics

• Animals
• Blood Pressure
• Edema (physiopathology)
• Extracellular Space
• Hexachlorophene
• Peripheral Nervous System Diseases (chemically induced, physiopathology)
• Rats
• Rats, Inbred Strains
• Sciatic Nerve (blood supply)
• Vasa Nervorum (physiopathology)