Activity of bis-carbamoyloxymethyl derivatives of pyrroles and pyrrolizines against human tumor xenografts in nude mice.

Abstract

The activities of the pyrrolizines, Compounds I and II, and the pyrroles, Compounds IV and V, are reported in nude mouse-grown HT-29 human adenocarcinoma of the colon, DO 1 human oat carcinoma of the lung, and CL 1 human duct cell carcinoma of the breast (coded as CX-1, LX-1, and MX-1, respectively, by the National Cancer Institute). Compounds II and IV were active against all three experimental tumors; both compounds produced significant tumor regression in the human breast tumor xenograft and Compound IV caused tumor regression in the human lung tumor xenograft.

• Authors: W K Anderson
• Journal: Cancer research (Cancer Res) Vol. 42 Issue 6 Pg. 2168-70 (Jun 1982) ISSN: 0008-5472 [Print] United States
• PMID: 6280852 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pyrroles
• Pyrrolidines

Topics

• Adenocarcinoma (drug therapy)
• Animals
• Breast Neoplasms (drug therapy)
• Carcinoma, Small Cell (drug therapy)
• Cell Line
• Colonic Neoplasms (drug therapy)
• Drug Evaluation, Preclinical
• Humans
• Lung Neoplasms (drug therapy)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Neoplasms (drug therapy)
• Neoplasms, Experimental (drug therapy)
• Pyrroles (therapeutic use)
• Pyrrolidines (therapeutic use)
• Transplantation, Heterologous