[Molecular organization of erythrocyte membranes in Duchenne muscular dystrophy].

Abstract

Lipid-soluble spin labels were used to study lipid protein interactions in erythrocyte membranes obtained from patients with Duchenne muscular dystrophy. The temperature dependence of order parameter (Sn) and correlation time (tau c) have demonstrated alterations in the surface and in the hydrophobic core of membrane; the differences might be correlated with a depletion of extrinsic protein and of intramembrane particles. Our studies suggest a great abnormality of membrane molecular organization in Duchenne muscular dystrophy.

• Authors: A M Falcioni, G Ferretti, L Mazzanti, G Curatola
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 57 Issue 23 Pg. 2307-12 (Dec 15 1981) ISSN: 0037-8771 [Print] Italy
• Vernacular Title: Studi sulla organizzazione molecolare della membrana eritrocitaria nella distrofia muscolare Duchenne.
• PMID: 6279127 (Publication Type: English Abstract, Journal Article)

Chemical References

• Membrane Lipids
• Membrane Proteins
• Spin Labels

Topics

• Electron Spin Resonance Spectroscopy
• Erythrocyte Membrane (metabolism)
• Erythrocytes (metabolism)
• Humans
• Membrane Lipids (blood)
• Membrane Proteins (blood)
• Muscular Dystrophies (blood)
• Spin Labels
• Surface Properties
• Temperature