[Usefulness of serum pseudocholinesterase isoenzymes in acute and chronic liver diseases and neoplasms (experimental and clinical study)].

Abstract

This paper was designed to study experimentally in rats hepatic and serum pseudocholinesterase, (CHE), and its isoenzyme activity, and also to analyze its behavior in acute hepatitis, cirrhosis and primary and secondary hepatic tumours. Five isoenzymes in rat liver homogenates and 4 to 5 in rat serum were found. In normal human serum 4 to 5 CHE-isoenzymes were recognized. Cuali and quantitative decreases in all serum CHE isoenzymes were found in all patients with severe liver disease. Isoenzyme No. 1 decreased significatively in cirrhotics, showing a double peak inscription. Isoenzyme No. 5 was elevated in the three patients with hepatoma.

• Authors: A Lemberg, M C Macchi
• Journal: Acta gastroenterologica Latinoamericana (Acta Gastroenterol Latinoam) Vol. 11 Issue 1 Pg. 125-32 ( 1981) ISSN: 0300-9033 [Print] Argentina
• Vernacular Title: Utilidad de las isoenzimas de la pseudocolinesterasa sérica en hepatopatías agudas, crónicas y neoplasias (estudio experimental y clínico).
• PMID: 6275651 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Butyrylcholinesterase
• Cholinesterases

Topics

• Adenoma (enzymology)
• Animals
• Butyrylcholinesterase (blood)
• Carcinoma, Hepatocellular (enzymology)
• Cholinesterases (blood)
• Densitometry
• Electrophoresis, Polyacrylamide Gel
• Hepatitis (enzymology)
• Humans
• Isoenzymes (blood)
• Liver (enzymology)
• Liver Cirrhosis (enzymology)
• Liver Diseases (enzymology)
• Liver Neoplasms (enzymology)
• Male
• Rats