Effect of dibutyryl adenosine 3',5'-monophosphate administration on plasma concentrations of 1,25-dihydroxyvitamin D in pseudohypoparathyroidism type I.

Abstract

The effect of dibutyryl cAMP on plasma concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D] was studied in two patients with pseudohypoparathyroidism (PHP) type I, five normal adults, and three normal children as controls. In normal adults, plasma 1,25-(OH)2D tended to increase 3 h after the infusion of 2.5 mg/kg dbcAMP and was significantly increased after 6 h. In normal children, plasma 1,25-(OH)2D increased 3 h after the infusion, then gradually decreased; in the patients with PHP type I, it increased greatly from 6.8 and 11.2 pg/ml to 264.6 and 128.2 pg/ml 3 h after the infusion. These results suggest that the renal mechanism for the response to parathyroid hormone is intact distal to the renal adenylate cyclase in patients with PHP type I.

• Authors: K Yamaoka, Y Seino, M Ishida, T Ishii, T Shimotsuji, Y Tanaka, H Kurose, S Matsuda, K Satomura, H Yabuuchi
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 53 Issue 5 Pg. 1096-100 (Nov 1981) ISSN: 0021-972X [Print] United States
• PMID: 6270183 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dihydroxycholecalciferols
• Phosphorus
• 24,25-Dihydroxyvitamin D 3
• Bucladesine
• Calcitriol

Topics

• 24,25-Dihydroxyvitamin D 3
• Adolescent
• Adult
• Bucladesine
• Calcitriol (blood)
• Child
• Dihydroxycholecalciferols (blood)
• Female
• Humans
• Kidney (physiopathology)
• Kidney Tubules (metabolism)
• Male
• Phosphorus (metabolism)
• Pseudohypoparathyroidism (blood)