ACTH in normal children and children with pituitary and adrenal diseases. I. Measurement in plasma by radioimmunoassay--basal values.

Abstract

Plasma ACTH was measured by radioimmunoassay including preliminary extraction onto adsorbent glass particles. Normal basal values for children 4-16 years of age were 11-82 microgram/ml, corresponding to values found in the literature. Normal values were found in girls with precocious puberty, children with McCune-Albright and Beckwith-Wiedemann's syndrome. Values between 233 and 305 pg/ml were found in untreated children with congenital adrenal hyperplasia. In primary Addison's disease, very high levels (654-1 413 pg/ml) before cortisone therapy and their decline to nearly normal values during therapy are described. ACTH values in a case of pituitary Cushing's syndrome was just above the normal range (104-163 microgram/ml).

• Authors: K E Petersen
• Journal: Acta paediatrica Scandinavica (Acta Paediatr Scand) Vol. 70 Issue 3 Pg. 341-5 ( 1981) ISSN: 0001-656X [Print] Sweden
• PMID: 6264733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adolescent
• Adrenal Gland Diseases (blood)
• Adrenocorticotropic Hormone (blood)
• Child
• Child, Preschool
• Female
• Humans
• Male
• Pituitary Diseases (blood)
• Radioimmunoassay
• Reference Values