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Hypomagnesemia and impaired parathyroid hormone secretion in chronic renal disease.

Abstract
Severe hypocalcemia secondary to magnesium depletion has been described in numerous patients with gastrointestinal disorders. The development of profound hypomagnesemia in chronic renal disease is a rare finding. We studied three patients with advanced renal failure and magnesium depletion. Severe hypocalcemia also was present in these patients. Despite hyperplasia of the parathyroid glands, the levels of immunoreactive parathyroid hormone (PTH) in blood were inappropriately low for the degree of renal insufficiency. After the administration of magnesium there was a significant increase in the levels of circulating i-PTH in serum with a concomitant improvement in the hypocalcemia.
AuthorsP Mennes, R Rosenbaum, K Martin, E Slatopolsky
JournalAnnals of internal medicine (Ann Intern Med) Vol. 88 Issue 2 Pg. 206-9 (Feb 1978) ISSN: 0003-4819 [Print] United States
PMID626450 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Parathyroid Hormone
  • Magnesium
Topics
  • Adult
  • Aged
  • Female
  • Humans
  • Hypocalcemia (drug therapy, etiology)
  • Kidney Failure, Chronic (complications, drug therapy)
  • Magnesium (therapeutic use)
  • Magnesium Deficiency (drug therapy, etiology)
  • Male
  • Parathyroid Hormone (blood)

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