Abstract |
Adenylate cyclase activity and the number of alpha- and beta-adrenergic receptors (studied by radioligand binding techniques) were compared to adipocyte membranes prepared from lipomatous and normal adjacent adipose tissue of a patient with multiple symmetric lipomatosis. No difference could be detected between the normal and lipomatous adipose biopsies. These data strongly suggest that the impairement of catecholamine-induced lipolysis often reported in lipomas is related to a defect in the enzymatic steps localized beyond rather than before cyclic AMP synthesis.
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Authors | R Pecquery, L Malagrida, Y Giudicelli |
Journal | Biomedicine / [publiee pour l'A.A.I.C.I.G.]
(Biomedicine)
Vol. 33
Issue 3
Pg. 64-6
(May 1980)
ISSN: 0300-0893 [Print] France |
PMID | 6256016
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Adrenergic
- Receptors, Adrenergic, alpha
- Receptors, Adrenergic, beta
- Adenylyl Cyclases
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Topics |
- Adenylyl Cyclases
(metabolism)
- Adipose Tissue
(metabolism)
- Animals
- Humans
- Lipomatosis
(metabolism)
- Male
- Middle Aged
- Rats
- Receptors, Adrenergic
(metabolism)
- Receptors, Adrenergic, alpha
(metabolism)
- Receptors, Adrenergic, beta
(metabolism)
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