Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis.

Abstract

Adenylate cyclase activity and the number of alpha- and beta-adrenergic receptors (studied by radioligand binding techniques) were compared to adipocyte membranes prepared from lipomatous and normal adjacent adipose tissue of a patient with multiple symmetric lipomatosis. No difference could be detected between the normal and lipomatous adipose biopsies. These data strongly suggest that the impairement of catecholamine-induced lipolysis often reported in lipomas is related to a defect in the enzymatic steps localized beyond rather than before cyclic AMP synthesis.

• Authors: R Pecquery, L Malagrida, Y Giudicelli
• Journal: Biomedicine / [publiee pour l'A.A.I.C.I.G.] (Biomedicine) Vol. 33 Issue 3 Pg. 64-6 (May 1980) ISSN: 0300-0893 [Print] France
• PMID: 6256016 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Adrenergic
• Receptors, Adrenergic, alpha
• Receptors, Adrenergic, beta
• Adenylyl Cyclases

Topics

• Adenylyl Cyclases (metabolism)
• Adipose Tissue (metabolism)
• Animals
• Humans
• Lipomatosis (metabolism)
• Male
• Middle Aged
• Rats
• Receptors, Adrenergic (metabolism)
• Receptors, Adrenergic, alpha (metabolism)
• Receptors, Adrenergic, beta (metabolism)