Granulosa-cell and theca-cell tumors. The clinical picture and long-term outcome for the Radiumhemmet series.

Abstract

Over the period 1923--72 a total of 305 patients with granulosa-cell, theca-cell tumor and mixed tumor were seen at Radiumhemmet. The commonest symptom was abnormal uterine bleeding. Twenty-three per cent of married women were nulliparous. The menarche seems to have occurred earlier in this group than in the general population. Eight of the granulosa-cell tumor group gave birth to 12 children after treatment for the tumor. Nineteen women with granulosa-cell tumor and 4 with thecoma had received radiotherapy earlier in life for benign lesions. The risk of endometrial cancer was approximately 10 times greater for the women with granulosa- or theca-cell tumor than for the general population. Two hundred and fifty-two patients were given both surgical treatment and radiotherapy. Fifty-three received only surgery (37 granulosa-cell and 16 theca-cell tumors). None of the thecoma patients but 21 per cent of those with granulosa-cell tumor died from their disease. The 5-year survival for the latter group, all stages, was 85 per cent.

• Authors: E Björkholm, F Pettersson
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 59 Issue 4 Pg. 361-5 ( 1980) ISSN: 0001-6349 [Print] United States
• PMID: 6255725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Female
• Follow-Up Studies
• Granulosa Cell Tumor (mortality, therapy)
• Humans
• Menarche
• Menopause
• Middle Aged
• Ovarian Neoplasms (mortality, therapy)
• Parity
• Prognosis
• Sweden
• Thecoma (mortality, therapy)
• Uterine Hemorrhage (complications)
• Uterine Neoplasms (complications)