Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs.

Hypokinesia produced by stereotaxic microinjection of solutions of 6-hydroxydopamine into the anterolateral hypothalamus of male rats is accompanied by a generalized reduction in brain noradrenaline levels and a reduction of dopamine in the striatum and cerebral cortex. The hypokinesia is reversed by the putative dopamine-receptor agonists apomorphine, ET-495 and CB-154 as well as by the amino acids L-Dopa and m-tyrosine when administered in combination with the peripheral decarboxylase inhibitor Ro 4-4602. The relative importance of noradrenergic and dopaminergic systems in the mediation of the action of anti-akinesia drugs is discussed.
AuthorsR F Butterworth, F Bélanger, A Barbeau
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 8 Issue 1 Pg. 41-5 (Jan 1978) ISSN: 0091-3057 [Print] UNITED STATES
PMID625480 (Publication Type: Journal Article)
Chemical References
  • Antiparkinson Agents
  • Hydroxydopamines
  • Receptors, Dopamine
  • Serotonin
  • Bromocriptine
  • Tyrosine
  • Levodopa
  • Piribedil
  • Apomorphine
  • Dopamine
  • Norepinephrine
  • Animals
  • Antiparkinson Agents (pharmacology)
  • Apomorphine (pharmacology)
  • Brain (metabolism)
  • Bromocriptine (pharmacology)
  • Dopamine (metabolism)
  • Hydroxydopamines (adverse effects)
  • Hypothalamus (physiology)
  • Hypothalamus, Anterior (drug effects, physiology)
  • Levodopa (pharmacology)
  • Male
  • Models, Neurological
  • Motor Activity (drug effects, physiology)
  • Norepinephrine (metabolism)
  • Piribedil (pharmacology)
  • Rats
  • Receptors, Dopamine (drug effects)
  • Serotonin (metabolism)
  • Tyrosine (pharmacology)

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