Abstract |
The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25( OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 microgram/kg D3, 2 microgram/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 microgram/kg 1 alpha,25( OH)2D3, and 0.1 or 0.2 microgram/kg 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1 alpha,25( OH)2D3 and 1 alpha OHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroir glands. The potency of 1 alpha OHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of 1 alpha,25( OH)2D3. The same dose level of 1 alpha OHD3 was more effective than 1 alpha,25( OH)2D3 in enhancing plasma 1 alpha,25( OH)2D3 levels.
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Authors | M Fukushima, R Niki, H Ohkawa, T Shimizu, I Matsunaga, H Nakano, Y Takagaki, Y Nishii, K Okano, T Suda |
Journal | Endocrinology
(Endocrinology)
Vol. 107
Issue 1
Pg. 328-33
(Jul 1980)
ISSN: 0013-7227 [Print] United States |
PMID | 6247140
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dihydroxycholecalciferols
- Glycopeptides
- Hydroxycholecalciferols
- Parathyroid Hormone
- Cholecalciferol
- Calcium
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Topics |
- Animals
- Bone and Bones
(drug effects, pathology)
- Calcium
(metabolism)
- Cholecalciferol
(pharmacology, therapeutic use)
- Chronic Kidney Disease-Mineral and Bone Disorder
(chemically induced, drug therapy, pathology)
- Dihydroxycholecalciferols
(pharmacology)
- Disease Models, Animal
- Glycopeptides
- Hydroxycholecalciferols
(pharmacology)
- Parathyroid Glands
(drug effects)
- Parathyroid Hormone
(blood)
- Rats
- Structure-Activity Relationship
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