Mecillinam and ampicillin separately or combined in gram-negative septicemia.

Abstract

Of 20 patients with gram-negative septicemia treated with mecillinam alone or in combination with ampicillin, successful therapeutic results were obtained in 16. In 11 patients treated with ampicillin alone, three failures responded successfully to a combination of mecillinam and ampicillin. Mecillinam MIC values of isolated Enterobacteriaceae were 0.05-0.4 micrograms/ml. In patients receiving 5 mg/kg mecillinam intravenously every six hours, the mean 0.5 hour concentration was 11.0 micrograms/ml and in those given 10 mg/kg 23.3 migcrograms/ml. No serious side effects were recorded. One patient on mecillinam developed an exanthema, as did three patients on combined therapy.

• Authors: E Ekwall, A Scheja, S Cronberg, K Ganrot-Norlin, M Jonsson, I Juhlin, G Kahlmeter, A Thorén, K E Thulin, G Tunevall
• Journal: Infection (Infection) Vol. 8 Issue 1 Pg. 37-40 ( 1980) ISSN: 0300-8126 [Print] Germany
• PMID: 6246006 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Ampicillin
• Penicillanic Acid
• Amdinocillin

Topics

• Adult
• Aged
• Amdinocillin (administration & dosage, adverse effects, metabolism, therapeutic use)
• Ampicillin (administration & dosage, adverse effects, metabolism, therapeutic use)
• Drug Therapy, Combination
• Enterobacteriaceae (drug effects)
• Enterobacteriaceae Infections (drug therapy)
• Exanthema (chemically induced)
• Female
• Half-Life
• Humans
• Kinetics
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Penicillanic Acid (therapeutic use)
• Sepsis (drug therapy)