Acute systemic anaphylaxis in adult domestic fowl: evidence for the protective role of H2-histaminergic and beta 2-adrenergic receptors.

Abstract

Pentobarbital-anesthetized and spontaneously breathing, bovine albumin (BA)-sensitized adult domestic fowl showed acute systemic anaphylaxis to IV injection of antigen (BA), which was characterized by arterial hypotension, central venous hypertension, and bradycardia. Large doses of pyrilamine maleate (/1-receptor antagonist) partially inhibited acute systemic anaphylaxis. On the other hand, metiamide (a specific H2-antagonist) and propranolol (beta-adrenergic antagonist) markedly enhanced the anaphylactic response. Terbutaline (beta 2-agonist), dimaprit (a highly selective H2-agonist), and compound FPL 55712 (a slow-reacting substance of anaphylaxis receptor antagonist) either significantly inhibited or reversed the anaphylactic response. Cimetidine (a newer H2-antagonist) enhanced only central venous pressor response to BA. This investigation appears to suggest a minor role of histamine and a major role of slow-reacting substance of anaphylaxis as chemical mediatiors of anaphylaxis. A protective role of beta 2-adrenergic and H2-histaminergic receptors seem to operate in immediate hypersensitivity reactions in adult domestic fowl.

• Authors: N Chand, L DeRoth
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 41 Issue 1 Pg. 101-5 (Jan 1980) ISSN: 0002-9645 [Print] United States
• PMID: 6244759 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chromones
• Ethers
• Receptors, Adrenergic
• Receptors, Adrenergic, beta
• Receptors, Histamine
• Receptors, Histamine H2
• Metiamide
• Cimetidine
• FPL 55712
• Propranolol
• Thiourea
• Pyrilamine
• Terbutaline
• Dimaprit

Topics

• Anaphylaxis (physiopathology, veterinary)
• Animals
• Blood Pressure (drug effects)
• Carotid Arteries (drug effects, physiopathology)
• Chickens
• Chromones (pharmacology)
• Cimetidine (pharmacology)
• Dimaprit
• Ethers (pharmacology)
• Heart Rate (drug effects)
• Metiamide (pharmacology)
• Poultry Diseases (physiopathology)
• Propranolol (pharmacology)
• Pyrilamine (pharmacology)
• Receptors, Adrenergic (physiology)
• Receptors, Adrenergic, beta (drug effects, physiology)
• Receptors, Histamine (physiology)
• Receptors, Histamine H2 (drug effects, physiology)
• Terbutaline (pharmacology)
• Thiourea (pharmacology)