Cerebral atrophy following ACTH therapy.

Abstract

In a study of 15 patients with infantile spasms and Lennox syndrome 4 (26.7%) showed no cerebral atrophy and 11 (73.3%) showed mild ventricular and sulcal enlargement before ACTH therapy. Ventricular and sulcal enlargement increased soon after ACTH therapy in most patients. Cerebral atrophy was reversible at over 1 month after ACTH therapy. However, in three instances, cerebral atrophy was not reversible, and one patient with infantile spasms had chronic subdural effusion, which appeared to be a complication of treatment with ACTH. Patients on ACTH therapy should be carefully monitored.

• Authors: T Okuno, M Ito, Y Konishi, M Yoshioka, Y Nakano
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) Vol. 4 Issue 1 Pg. 20-3 (Feb 1980) ISSN: 0363-8715 [Print] United States
• PMID: 6243678 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (adverse effects)
• Atrophy
• Brain Diseases (chemically induced, diagnostic imaging)
• Child, Preschool
• Epilepsies, Myoclonic (drug therapy)
• Female
• Humans
• Infant
• Male
• Spasm (drug therapy)
• Tomography, X-Ray Computed