Platelet aggregation, beta-thromboglobulin and platelet factor 4 in diabetes mellitus and in patients with vasculopathy.

Abstract

We have studied 155 subjects, 48 normals, 36 diabetics without complications, 44 with complications and 27 patients with macroangiopathy. beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) are elevated in the patients groups. There is no correlation between the plasma levels of beta-TG and the stages of either retinopathy or macroangiopathy or nephropathy. The difference is more marked between normals and diabetics with neuropathy (p = 0.026). The aggregation response to ADP and platelet activating factor (PAF) is enhanced at lower stimulator concentration. Using the beta-TG, PF4 and aggregation values the discriminant analysis allows a distinction of several subgroups especially with nephropathy and neuropathy (Table 6).

• Authors: J Fritschi, M Christe, B Lämmle, G A Marbet, W Berger, F Duckert
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 52 Issue 3 Pg. 236-9 (Dec 29 1984) ISSN: 0340-6245 [Print] Germany
• PMID: 6241750 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• beta-Thromboglobulin
• Platelet Factor 4

Topics

• Blood Platelets (physiology)
• Diabetes Mellitus (blood)
• Diabetic Angiopathies (blood)
• Diabetic Nephropathies (blood)
• Diabetic Neuropathies (blood)
• Humans
• Platelet Aggregation
• Platelet Factor 4 (analysis)
• Vascular Diseases (blood)
• beta-Thromboglobulin (analysis)