[Treatment of renal colic with intravenous ketoprofen].

Abstract

In view of the part played by renal prostaglandins in the mechanisms responsible for pain in renal colic, it was worth trying to find out whether nonsteroidal anti-inflammatory agents, which inhibit prostaglandin synthesis, have an analgesic effect of their own. In a double-blind trial the effects of ketoprofen 100 mg administered intravenously alone or associated with noramidopyrine were investigated in 62 patients divided at random into two equal groups. A rapid analgesic effect was observed with no significant difference between the groups. No severe side-effects were recorded. The double-blind method made it possible to confirm that ketoprofen administered alone relieved pain in 97% of the patients (with complete sedation in 45%) and acted within 5 minutes. Owing to their effectiveness and safety nonsteroidal anti-inflammatory drugs (especially ketoprofen) may be proposed as an alternative to conventional treatments of renal colic. But because of their activity they should not be prescribed until a firm diagnosis has been made. The cause of the colic should also be rapidly determined in order to treat it as well as the pain it produces.

• Authors: J P Pourrat, J M Dueymes, J J Conte
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 13 Issue 35 Pg. 2125-8 (Oct 06 1984) ISSN: 0755-4982 [Print] France
• Vernacular Title: Traitement de la colique néphrétique par le kétoprofène intraveineux.
• PMID: 6238315 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Phenylpropionates
• Ketoprofen

Topics

• Adult
• Aged
• Colic (drug therapy)
• Double-Blind Method
• Drug Evaluation
• Emergencies
• Female
• Humans
• Injections, Intravenous
• Ketoprofen (administration & dosage, therapeutic use)
• Kidney Diseases (drug therapy)
• Male
• Middle Aged
• Phenylpropionates (therapeutic use)