Abstract |
A new drug, Cyclobenzaprine hydrochloride ( Flexeril), was compared with diazepam ( Valium) and placebo in double-blind trials for efficacy in treating spasms and pain in the neck and low back. Complex recording methods involving clinical evaluations (graded), patient self-ratings, goniometry, motion analysis by computer, electromyography of controlled motions and detailed statistical analysis were used. Clinical improvement over two weeks was statistically significant in all treatment groups with a statistically significant preference for Cyclobenzaprine hydrochloride. The most striking improvements recorded were in the electromyographic findings, which showed statistically significant changes for the Cyclobenzaprine group. Clinical muscle spasms are not accompanied by increased myoelectric activity; the reverse is true. With improvement, myoelectric activity in back muscles is augmented during prescribed stressful movements as measured by electromyography and computer analysis combined with complex electrogoniometry.
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Authors | J V Basmajian |
Journal | Archives of physical medicine and rehabilitation
(Arch Phys Med Rehabil)
Vol. 59
Issue 2
Pg. 58-63
(Feb 1978)
ISSN: 0003-9993 [Print] United States |
PMID | 623512
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Dibenzocycloheptenes
- Muscle Relaxants, Central
- Placebos
- Amitriptyline
- cyclobenzaprine
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Topics |
- Administration, Oral
- Amitriptyline
(analogs & derivatives)
- Computers
- Dibenzocycloheptenes
(administration & dosage, adverse effects, therapeutic use)
- Double-Blind Method
- Drug Evaluation
- Electromyography
- Humans
- Lumbosacral Region
- Movement
- Muscle Relaxants, Central
(administration & dosage, adverse effects, therapeutic use)
- Muscle Spasticity
(drug therapy)
- Neck
- Placebos
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