Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin.

Abstract

Norfloxacin, an orally administered quinoline carboxylic acid that is structurally related to nalidixic acid, has been shown to be highly active in vitro against penicillinase-producing Neisseria gonorrhoeae. Ninety-two men with culture-proved gonococcal urethritis, 46 per cent with penicillinase-producing N. gonorrhoeae, and 27 per cent with non-penicillinase-producing N. gonorrhoeae that was resistant to penicillin were given either 1200 mg of norfloxacin divided into two equal oral doses four hours apart (59 patients) or 2 g of spectinomycin intramuscularly (33 patients). All patients in both treatment groups were cured. No adverse reactions were reported in either group. We conclude that a two-dose, single-day regimen of orally administered norfloxacin is effective therapy for uncomplicated urethritis caused by penicillin-resistant strains of N. gonorrhoeae.

• Authors: S R Crider, S D Colby, L K Miller, W O Harrison, S B Kerbs, S W Berg
• Journal: The New England journal of medicine (N Engl J Med) Vol. 311 Issue 3 Pg. 137-40 (Jul 19 1984) ISSN: 0028-4793 [Print] United States
• PMID: 6234465 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anti-Bacterial Agents
• Penicillins
• Nalidixic Acid
• Spectinomycin
• Norfloxacin

Topics

• Administration, Oral
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Drug Tolerance
• Gonorrhea (drug therapy, microbiology)
• Humans
• Male
• Nalidixic Acid (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Neisseria gonorrhoeae (drug effects)
• Norfloxacin
• Penicillin Resistance
• Penicillins (pharmacology)
• Spectinomycin (therapeutic use)
• Urethritis (drug therapy)