[Monotherapy of Pseudomonas aeruginosa septicemia with azlocillin].

Abstract

Azlocillin was administered alone to seven patients without malignant or blood disease presenting with septicaemia caused by Pseudomonas aeruginosa. In 6 cases the infection developed after surgery and in 3 of these it was responsible for a state of shock, twice associated with acute anuric renal failure. The minimum inhibitory concentrations of azlocillin varied from 2 to 32 micrograms/ml; 5 strains were resistant to carbenicillin. The minimum inhibitory to minimum bactericidal concentrations ratio, measured on five occasions, was equal to 2. Bacterial eradication was obtained in 6 patients. One patient with multivisceral failure died during treatment and in this case the responsible organism had become resistant to azlocillin.

• Authors: J Godard, J Aubertin, J C Borderon, J B Dureux, J Motin
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 13 Issue 13 Pg. 819-21 (Mar 29 1984) ISSN: 0755-4982 [Print] France
• Vernacular Title: Monothérapie des septicémies à Pseudomonas aeruginosa par azlocilline.
• PMID: 6231603 (Publication Type: Case Reports, Journal Article)

Chemical References

• Penicillins
• Carbenicillin
• Azlocillin

Topics

• Adult
• Aged
• Azlocillin
• Carbenicillin (pharmacology)
• Female
• Humans
• Male
• Middle Aged
• Penicillin Resistance
• Penicillins (therapeutic use)
• Postoperative Complications (drug therapy)
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects)
• Sepsis (drug therapy)
• Shock, Septic (etiology)