Interleukin 2 (IL-2) activity during tumor growth: IL-2 production kinetics, absorption of and responses to exogenous IL-2.

Abstract

A temporal study assessed the relationship between fibrosarcoma growth and immunologic encumbrance due to the inability of BALB/c mouse splenocytes to elaborate the lymphokine Interleukin 2 (IL-2). Nylon-wool fractionation and antiserum treatments suggested the existence of a mildly nylon-wool-adherent, anti-Lyt 2-sensitive tumor-induced suppressor T (Ts) cell which significantly decreased IL-2 activity. Absorption investigations indicated that ligand-activated tumor-bearing host (TBH) spleen cells were less receptive to IL-2 than their normal counterparts. When splenocytes were antiserum treated before absorption, removal of Lyt 2+ (suppressor T) cells resulted in greater IL-2 absorption by the remaining cells. Purified IL-2 only partially restored suppressed TBH spleen cell mitogen- or alloantigen-induced blastogenesis; whereas, normal host reactivity was significantly augmented. The collective data suggest that TBH spleen cells were capable of producing IL-2 and of responding to the IL-2 amplification signal when tumor-induced Ts cells were depleted.

• Authors: C J Burger, K D Elgert, W L Farrar
• Journal: Cellular immunology (Cell Immunol) Vol. 84 Issue 2 Pg. 228-39 (Apr 01 1984) ISSN: 0008-8749 [Print] Netherlands
• PMID: 6231106 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Interleukin-2

Topics

• Absorption
• Animals
• Cell Transformation, Neoplastic (pathology)
• Fibrosarcoma (immunology, metabolism, pathology)
• Interleukin-2 (biosynthesis, metabolism, physiology)
• Kinetics
• Lymphocyte Activation
• Male
• Mice
• Mice, Inbred BALB C
• Spleen (cytology, immunology, metabolism)
• T-Lymphocytes, Cytotoxic (immunology)
• T-Lymphocytes, Regulatory (immunology)