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The safety of zimeldine in long-term use in depressive illness.

Abstract
The aim of this study was to evaluate the safety of zimeldine, a 5-HT reuptake inhibitor, in the long-term treatment of depressive disorders. The study was an open label, multicentre investigation involving 147 patients who were suffering from depressive illness and who needed long-term anti-depressant treatment. Sixty-five patients completed the intended treatment period of 1 year, 75 terminated prematurely, and 7 are still in the programme. The reasons for termination were mainly ineffectiveness of the drug and adverse reactions. During the long-term treatment the most common emergent symptoms were, in order of decreasing frequency, dizziness, dry mouth, sleep disorders, sweating, tremor, nausea and headache. The side-effects were, however, mild and they generally decreased during the treatment period. No new adverse symptoms were reported. In the long-term treatment group, body weight showed a slight mean decrease. Clinical chemistry and cardiovascular investigations were judged to show no changes of clinical importance. It is concluded that zimeldine was shown to be a safe drug in this 1-year treatment programme of depression.
AuthorsJ Wålinder, A Arberg-Wistedt, H Jozwiak, L von Knorring, C Nyström
JournalActa psychiatrica Scandinavica. Supplementum (Acta Psychiatr Scand Suppl) Vol. 308 Pg. 147-60 ( 1983) ISSN: 0065-1591 [Print] Denmark
PMID6230889 (Publication Type: Journal Article)
Chemical References
  • Zimeldine
  • Creatinine
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
Topics
  • Adolescent
  • Adult
  • Aged
  • Alanine Transaminase (blood)
  • Alkaline Phosphatase (blood)
  • Aspartate Aminotransferases (blood)
  • Body Weight (drug effects)
  • Child
  • Creatinine (blood)
  • Depressive Disorder (drug therapy)
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nausea (chemically induced)
  • Sleep Wake Disorders (chemically induced)
  • Time Factors
  • Zimeldine (adverse effects)

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