In Brown-Norway (BN) rats,
oral administration of
mercuric chloride (
HgCl2) induced morphological lesions of the ileum and, in lesser degree, of the colon, with abnormal deposits of
IgA in the basement membranes of intestinal glands and of
IgG in the basement membranes and in the lamina propria.
IgG reactive with renal and intestinal basement membranes and in the lamina propria.
IgG reactive with renal and intestinal basement membranes and with the lamina propria of a normal BN rat was found in the serum and
IgG deposits were present in renal glomeruli of BN rats receiving
HgCl2. Thus, it is conceivable that the deposits of
IgG present in the intestine resulted from local fixation of circulating
autoantibodies. In contrast,
IgA with basement membrane reactivity was not detected in the sera nor in the renal glomeruli, suggesting that the intestinal deposits of
IgA were formed in situ. This
IgA-
IgG intestinal disease inducible in BN rats may provide a model for the study of alterations of the
secretory IgA system, as well as for testing the possibility that abnormal deposits
IgA-
IgG in the intestinal structures are associated with local functional changes.