L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment.

Abstract

L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.

• Authors: M M Wick
• Journal: Science (New York, N.Y.) (Science) Vol. 199 Issue 4330 Pg. 775-6 (Feb 17 1978) ISSN: 0036-8075 [Print] United States
• PMID: 622565 (Publication Type: Journal Article)

Chemical References

• Levodopa
• Benserazide
• Leucine
• Thymidine
• Uridine

Topics

• Animals
• Benserazide (pharmacology)
• Cell Line
• Drug Synergism
• Leucine (metabolism)
• Levodopa (analogs & derivatives, pharmacology, therapeutic use)
• Male
• Mice
• Neoplasms, Experimental (drug therapy, metabolism)
• Neuroblastoma (drug therapy, metabolism)
• Thymidine (metabolism)
• Uridine (metabolism)