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HLA-B27 associated arthropathies.

Abstract
The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether specific radiographic changes predicted antigenic status. The prevalences of the HLA-B27 antigen in our patients were: ankylosing spondylitis, 100%; Reiter's arthritis, 93%; psoriatic arthritis, 55%; and ankylosing hyperostosis, 12%. The only specific radiographic finding associated with B27 positivity was severe spondylitis in psoriasis.
AuthorsT M Schumacher, H K Genant, M J Kellet, J C Mall, K H Fye
JournalRadiology (Radiology) Vol. 126 Issue 2 Pg. 289-97 (Feb 1978) ISSN: 0033-8419 [Print] United States
PMID622470 (Publication Type: Journal Article)
Chemical References
  • HLA Antigens
Topics
  • Arthritis (diagnostic imaging, immunology)
  • Arthritis, Reactive (diagnostic imaging, immunology)
  • HLA Antigens (analysis)
  • Humans
  • Psoriasis (diagnostic imaging, immunology)
  • Radiography
  • Spinal Osteophytosis (diagnostic imaging, immunology)
  • Spondylitis, Ankylosing (diagnostic imaging, immunology)

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