[Immunologic phenomena in habitual abortion].

Abstract

12 women with recurrent abortions are investigated for various immunological parameters. Couples studied shared several HLA antigens, those women do not develop HLA' antibodies and cellular cytotoxicity against their husband. Their serum has an abnormal glycoprotein, migrating in the alpha globulin zone, precipitating with anti beta globulin serum. The women studied with recurrent abortions never possessed the Blocking Factor present in the serum of pregnant women, able to inhibit a cellular cytotoxicity reaction in vitro. It is proposed a reliable and simple test which could inform on the outcome of abortions.

• Authors: J Bousquet, D Fizet, F Grobon, J P Dubecq
• Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales (C R Seances Soc Biol Fil) Vol. 176 Issue 5 Pg. 656-62 ( 1982) ISSN: 0037-9026 [Print] France
• Vernacular Title: Phénomènes immunologiques au cours des avortements répétés.
• PMID: 6220768 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA Antigens
• Immunoglobulin G

Topics

• Abortion, Habitual (immunology)
• Chromatography, Gel
• Cytotoxicity Tests, Immunologic
• Electrophoresis, Polyacrylamide Gel
• Female
• HLA Antigens (immunology)
• Humans
• Immunoglobulin G (analysis)
• Male
• Pregnancy