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Development of chronic pulmonary inflammation in immunized guinea pigs by aerosol challenge with antigen: relationship of immune complex disease and cell-mediated hypersensitivity.

Abstract
Immunized guinea pigs develop immune complex disease (ICD) in the lungs after a single aerosol challenge with specific antigen. In the current study, immunized guinea pigs developed chronic pulmonary inflammation and cellular immunity (CI) in the lungs when aerosol challenged daily with specific antigen for 2 wk. When immune serum was passively transferred to normal recipients that were then aerosol challenged with specific antigen for 2 wk, chronic pulmonary inflammation and CI did not develop. These results suggest that ICD produced by passive transfer of serum and subsequent aerosol exposure to antigen was inadequate to cause chronic pulmonary inflammation and CI. The development of chronic pulmonary inflammation by aerosol challenge with antigen was suppresed with cobra venom factor. However, because of other studies, we attribute this suppression to the diminution of complement (C) factors in the alternative C pathway that affect macrophage mobility rather than to the depletion of C5a, which is important in the development of ICD.
AuthorsY Yoshizawa, T Nakazawa, L M Ripani, V L Moore
JournalThe Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 70 Issue 2 Pg. 114-9 (Aug 1982) ISSN: 0091-6749 [Print] United States
PMID6212608 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Aerosols
  • Antigens
  • Immune Sera
  • Ovalbumin
Topics
  • Aerosols
  • Animals
  • Antigens (administration & dosage)
  • Female
  • Guinea Pigs
  • Immune Complex Diseases (immunology)
  • Immune Sera (pharmacology)
  • Immunity, Cellular
  • Ovalbumin (immunology)
  • Pneumonia (immunology)
  • Respiratory Hypersensitivity (immunology)

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