Plasma beta-thromboglobulin concentration at rest and after physical exercise in complicated and uncomplicated diabetes mellitus.

Abstract

Plasma beta-thromboglobulin concentration was measured in ten uncomplicated insulin-dependent diabetic subjects, in ten insulin-dependent patients with retinopathy and in ten age- and sex-matched healthy controls, both at rest and after cycloergometric exercise to exhaustion. Resting plasma beta-thromboglobulin was similar in the two patient groups and significantly higher than the control group. After exercising, plasma beta-thromboglobulin rose significantly only in the control group. Platelet hyperactivity is therefore present even in uncomplicated diabetes mellitus and is not influenced by the presence of complications. A chronic overstimulation of platelets could be responsible for the high basal plasma beta-thromboglobulin concentration in diabetes mellitus and for its abnormal behaviour after physical exercise.

• Authors: A M Vicari, A Margonato, P Petrelli, G G Vicedomini, G Pozza
• Journal: Diabete & metabolisme (Diabete Metab) Vol. 10 Issue 4 Pg. 235-8 (Oct 1984) ISSN: 0338-1684 [Print] France
• PMID: 6210218 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Beta-Globulins
• Glycated Hemoglobin A
• beta-Thromboglobulin

Topics

• Adult
• Beta-Globulins (analysis)
• Diabetes Mellitus, Type 1 (blood)
• Diabetic Angiopathies (blood)
• Diabetic Retinopathy (blood)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Male
• Physical Exertion
• Rest
• beta-Thromboglobulin (analysis)