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Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe.

Abstract
Between 1973 and 1982, 110 patients with advanced Hodgkin's disease who had had disease progression while receiving MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) chemotherapy or a relapse after a MOPP-induced complete remission were treated with either ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) (58 patients) or B-CAVe (bleomycin, lomustine, doxorubicin, and vinblastine) (52 patients) chemotherapy in concurrent nonrandomized trials. Responses were seen in 39 of 55 (71%) evaluable ABVD-treated patients--21 (38%) complete and 18 partial responses--and in 34 of 48 (71%) evaluable B-CAVe-treated patients--21 (44%) complete and 13 partial responses. The median duration of the ABVD-induced complete remissions is greater than 25 months compared with 24.3 months for B-CAVe-induced remissions. The 5-year actuarial freedom from progression is 8.5% for evaluable ABVD-treated patients and 25% for B-CAVe-treated patients (p = 0.10). Toxicity in the two treatment groups was similar, with only significant thrombocytopenia (platelet count, less than 50 000/mm3) being more common with B-CAVe. Although most patients with Hodgkin's disease refractory to MOPP treatment will respond to either ABVD or B-CAVe chemotherapy, subsequent long-term disease-free survival is unusual. The need for improved treatment programs for this patient group is evident.
AuthorsW G Harker, P Kushlan, S A Rosenberg
JournalAnnals of internal medicine (Ann Intern Med) Vol. 101 Issue 4 Pg. 440-6 (Oct 1984) ISSN: 0003-4819 [Print] United States
PMID6206757 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Bleomycin
  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Vinblastine
  • Lomustine
  • Dacarbazine
  • Doxorubicin
  • Prednisone
Topics
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Bleomycin (administration & dosage, adverse effects)
  • Combined Modality Therapy
  • Dacarbazine (administration & dosage, adverse effects)
  • Doxorubicin (administration & dosage, adverse effects)
  • Drug Resistance
  • Female
  • Heart Diseases (chemically induced)
  • Hodgkin Disease (drug therapy)
  • Humans
  • Lomustine (administration & dosage, adverse effects)
  • Lung Diseases (chemically induced)
  • Male
  • Mechlorethamine (administration & dosage)
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prednisone (administration & dosage)
  • Procarbazine (administration & dosage)
  • Vinblastine (administration & dosage, adverse effects)
  • Vincristine (administration & dosage)

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