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The influence of ultraviolet B irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha in psoriatic and normal subjects.

Abstract
The influence of ultraviolet B (UVB) irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 7 normal male volunteers and 7 male patients with stable psoriasis was examined. The excretion of PGF-MUM was increased during the first 24 hours after UVB irradiation of back skin and was generally reduced to near pre-irradiation levels during the next 24 hours after irradiation, in both normal and psoriatic subjects. Although pre-irradiation levels of PGF-MUM excretion in psoriatic patients were lower than those in normal subjects as previously reported, it was demonstrated that PGF-MUM excretion after UVB irradiation in psoriatic patients was fairly increased and amounted to near the mean pre-irradiation level in normal subjects. These results suggested not only a disorder in endogenous prostaglandin synthesis in psoriatic patients but a considerable capacity of psoriatic skin to synthesize prostaglandin after UVB irradiation.
AuthorsH Katayama, H Hori
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 64 Issue 1 Pg. 1-4 ( 1984) ISSN: 0001-5555 [Print] SWEDEN
PMID6203274 (Publication Type: Journal Article)
Chemical References
  • Fatty Acids
  • Prostaglandins F
  • Prostanoic Acids
  • prostaglandin F-main urinary metabolite
Topics
  • Adult
  • Aged
  • Fatty Acids (urine)
  • Humans
  • Male
  • Middle Aged
  • Prostaglandins F
  • Prostanoic Acids (urine)
  • Psoriasis (radiotherapy, urine)
  • Ultraviolet Therapy

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