Abstract |
Three commercial, intravenously applicable human IgG preparations passively protected NMRI mice against intraperitoneal challenge with 11 of 19 selected, serologically defined O-antigen reference strains and clinical, nosocomially significant isolates of Serratia marcescens. Conventional anti-O and anti-H, but not anti-K and anti- protease, rabbit immune sera revealed passive protective capacity against homologous challenge strains; however, anti-O rabbit immune sera failed to invariably protect against heterologous test strains that carried identical serogroup O-antigens. The passive protective efficacy of anti-live cell immune sera, derived from rabbits following recovery from experimental septicemia, was abolished through dual absorption with homologous O-cells. It was concluded that antibodies directed against O-antigens, i.e., lipopolysaccharide moieties, of the challenge strains of S. marcescens afforded passive protection.
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Authors | W H Traub |
Journal | Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...
(Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol)
Vol. 254
Issue 4
Pg. 480-8
(Jul 1983)
ISSN: 0174-3031 [Print] Germany |
PMID | 6202079
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens
- Antigens, Bacterial
- Antigens, Surface
- H antigen
- Immune Sera
- Immunoglobulin G
- K antigens
- O Antigens
- Peptide Hydrolases
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Topics |
- Agglutination Tests
- Animals
- Antigens
(immunology)
- Antigens, Bacterial
(immunology)
- Antigens, Surface
- Enterobacteriaceae Infections
(prevention & control)
- Female
- Humans
- Immune Sera
- Immunization, Passive
(methods)
- Immunoglobulin G
(immunology)
- Male
- Mice
- Mice, Inbred Strains
- O Antigens
- Peptide Hydrolases
(immunology)
- Rabbits
(immunology)
- Serratia marcescens
(immunology)
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