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Passive protection of NMRI mice against Serratia marcescens: comparative efficacy of commercial human IgG immunoglobulin preparations and rabbit anti-O, -H, -K, -life cell and -protease immune sera.

Abstract
Three commercial, intravenously applicable human IgG preparations passively protected NMRI mice against intraperitoneal challenge with 11 of 19 selected, serologically defined O-antigen reference strains and clinical, nosocomially significant isolates of Serratia marcescens. Conventional anti-O and anti-H, but not anti-K and anti-protease, rabbit immune sera revealed passive protective capacity against homologous challenge strains; however, anti-O rabbit immune sera failed to invariably protect against heterologous test strains that carried identical serogroup O-antigens. The passive protective efficacy of anti-live cell immune sera, derived from rabbits following recovery from experimental septicemia, was abolished through dual absorption with homologous O-cells. It was concluded that antibodies directed against O-antigens, i.e., lipopolysaccharide moieties, of the challenge strains of S. marcescens afforded passive protection.
AuthorsW H Traub
JournalZentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... (Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol) Vol. 254 Issue 4 Pg. 480-8 (Jul 1983) ISSN: 0174-3031 [Print] Germany
PMID6202079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens
  • Antigens, Bacterial
  • Antigens, Surface
  • H antigen
  • Immune Sera
  • Immunoglobulin G
  • K antigens
  • O Antigens
  • Peptide Hydrolases
Topics
  • Agglutination Tests
  • Animals
  • Antigens (immunology)
  • Antigens, Bacterial (immunology)
  • Antigens, Surface
  • Enterobacteriaceae Infections (prevention & control)
  • Female
  • Humans
  • Immune Sera
  • Immunization, Passive (methods)
  • Immunoglobulin G (immunology)
  • Male
  • Mice
  • Mice, Inbred Strains
  • O Antigens
  • Peptide Hydrolases (immunology)
  • Rabbits (immunology)
  • Serratia marcescens (immunology)

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