A striatal serotonergic involvement in the behavioural effects of anticholinesterase organophosphates.

Abstract

Acute administration of the anticholinesterase agents diisopropylfluorophosphate, soman, sarin and tabun to rats in sub-convulsive doses produced tremors and hind-limb abduction. The ratios of the levels of 5-HIAA to 5-HT in the striatum showed a consistent tendency to be increased, suggesting an increase in 5-HT turnover. Both the behavioural and the biochemical changes were antagonized by atropine. The possible involvement of a cholinergic-serotonergic interaction in these tremors and hind-limb abduction is discussed.

• Authors: J C Fernando, B H Hoskins, I K Ho
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 98 Issue 1 Pg. 129-32 (Feb 10 1984) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6201369 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Cholinesterase Inhibitors
• Insecticides
• Organophosphorus Compounds
• Serotonin
• Hydroxyindoleacetic Acid
• Atropine

Topics

• Animals
• Atropine (pharmacology)
• Behavior, Animal (drug effects)
• Cholinesterase Inhibitors (pharmacology)
• Corpus Striatum (physiology)
• Drug Interactions
• Hydroxyindoleacetic Acid (metabolism)
• Insecticides (pharmacology)
• Male
• Organophosphorus Compounds
• Rats
• Rats, Inbred Strains
• Serotonin (metabolism, physiology)
• Tremor (chemically induced)