CSF monoamine metabolism in patients with tardive dyskinesia: effect of oxypertine and hydroxyzine pamoate.

Abstract

Cerebrospinal fluid (CSF) HVA, MHPG, 5-HIAA, cAMP and cGMP concentrations were measured in schizophrenic patients with tardive dyskinesia before and after a three-week administration of oxypertine (n = 4), hydroxyzine pamoate (n = 4) or placebo (n = 4). The oxypertine administration resulted in a reduction of the CSF HVA concentration and an elevation of the MHPG and cAMP concentrations, associated with a clinical improvement in tardive dyskinesia. The hydroxyzine administration reduced the CSF 5-HIAA concentration in all the patients and the CSF HVA concentration in two of four patients with a clinical improvement. A reduction in the CSF HVA concentration associated with possible therapeutic effects of oxypertine or hydroxyzine may suggest the normalization of a hyperdopaminergic state. Discussions were held that functional disorders of not only the dopaminergic system but the norepinephrinergic and serotoninergic systems may relate to the pathogenesis of tardive dyskinesia.

• Authors: K Akiyama, T Nagao, M Yamamoto, A Fujimoto, T Ebara, M Sato, S Otsuki
• Journal: Folia psychiatrica et neurologica japonica (Folia Psychiatr Neurol Jpn) Vol. 37 Issue 2 Pg. 129-35 ( 1983) ISSN: 0015-5721 [Print] Japan
• PMID: 6200411 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biogenic Amines
• Indoles
• Piperazines
• Hydroxyzine
• Methoxyhydroxyphenylglycol
• Hydroxyindoleacetic Acid
• Cyclic AMP
• Cyclic GMP
• Homovanillic Acid

Topics

• Biogenic Amines (cerebrospinal fluid)
• Clinical Trials as Topic
• Cyclic AMP (cerebrospinal fluid)
• Cyclic GMP (cerebrospinal fluid)
• Dyskinesia, Drug-Induced (cerebrospinal fluid, drug therapy)
• Female
• Homovanillic Acid (cerebrospinal fluid)
• Humans
• Hydroxyindoleacetic Acid (cerebrospinal fluid)
• Hydroxyzine (therapeutic use)
• Indoles (therapeutic use)
• Male
• Methoxyhydroxyphenylglycol (cerebrospinal fluid)
• Piperazines (therapeutic use)