[Polyadenylated RNA and poly-A segments in the splenic cells of mice with virus-induced Rauscher leukemia].

Abstract

In spleen cells of mice with Rauscher++ leukosis polyadenilation of RNA was impaired: an increase in content of Gya poly(A)+ RNA and a change in the composition of poly-A-segments were observed. In DNA of leukemic and normal cells dA-fragments were found content of which was increased in leukemic cells as compared with normal ones. Leukemic transformation appears to be accompanied by appearance of the additional poly-A-fragments in the cells.

• Authors: I A Smirnova, N V Nakonechnyĭ
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1983 Nov-Dec Vol. 29 Issue 6 Pg. 63-9 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Poliadenilirovannye RNK i poli-A-segmenty v kletkakh selezenki mysheĭ s virusindutsirovannym leĭkozom Raushera.
• PMID: 6199896 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Viral
• RNA, Messenger
• Poly A
• RNA

Topics

• Animals
• Cell Transformation, Neoplastic
• DNA, Viral (metabolism)
• Electrophoresis, Agar Gel
• Leukemia, Experimental (metabolism)
• Mice
• Mice, Inbred BALB C
• Poly A (metabolism)
• RNA (metabolism)
• RNA, Messenger
• Rauscher Virus
• Spleen (metabolism)