Abstract |
Repetitive extrasystole and fibrillation thresholds were assessed by various methods of programmed atrial and ventricular stimulation using intracavitary bipolar electrode catheters and a microcomputer based 3-channel stimulator as previously described. "2nd Phase" ventricular arrhythmias were produced by ligation of the left descending coronary artery. 2,5-Bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate ( flecainide, R 818, Tambocor) caused a significant increase of the atrial and ventricular fibrillation thresholds. The antifibrillatory action was similar in atrial and ventricular tissues. "2nd Phase" ventricular arrhythmias were dose-dependently reduced or abolished completely. Similar doses were required to suppress spontaneous arrhythmic activity and to increase the fibrillation thresholds. Thus, flecainide proved to be a powerful antiarrhythmic agent with strong antifibrillatory properties in therapeutic doses. It may be a promising drug for the treatment of atrial and ventricular reentrant arrhythmias.
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Authors | H Heuer, H Gülker, J Thale, F Bender |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 33
Issue 12
Pg. 1651-4
( 1983)
ISSN: 0004-4172 [Print] Germany |
PMID | 6199033
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Arrhythmia Agents
- Piperidines
- Flecainide
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Topics |
- Animals
- Anti-Arrhythmia Agents
- Cardiac Complexes, Premature
(physiopathology)
- Dogs
- Electric Stimulation
- Female
- Flecainide
- Heart
(drug effects)
- Male
- Myocardial Infarction
(physiopathology)
- Piperidines
(pharmacology)
- Ventricular Fibrillation
(physiopathology)
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