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Monoclonal antibodies against pregnancy-specific beta 1-glycoprotein (SP1) in immunohistochemistry and radioimmunoassay.

Abstract
Monoclonal mouse antibodies against pregnancy-specific beta-1-glycoprotein (SP1) have been studied for their suitability in immunoperoxidase staining and radioimmunoassay methodologies. These antibodies were useful in staining normal placentas, hydatidiform moles, invasive moles and choriocarcinomas. They showed good specificity, with minimal background staining, and will thus be superior to conventional polyclonal antisera in immunohistochemistry. However, the presently tested monoclonal anti-SP1 antibodies were found not to be suitable for radioimmunoassay.
AuthorsT Wahlström, M Heikinheimo
JournalOncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine (Oncodev Biol Med) Vol. 4 Issue 6 Pg. 423-7 ( 1983) ISSN: 0167-1618 [Print] Netherlands
PMID6196757 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Immune Sera
  • Pregnancy Proteins
  • Pregnancy-Specific beta 1-Glycoproteins
Topics
  • Animals
  • Antibodies, Monoclonal
  • Choriocarcinoma (metabolism)
  • Female
  • Hydatidiform Mole (metabolism)
  • Immune Sera
  • Immunoenzyme Techniques
  • Mice
  • Placenta (metabolism)
  • Pregnancy
  • Pregnancy Proteins (analysis)
  • Pregnancy-Specific beta 1-Glycoproteins (analysis, immunology)
  • Rabbits
  • Radioimmunoassay
  • Staining and Labeling

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