[What may be expected of palliative chemotherapy of recurrent tumors of the upper airways and the digestive tract?].

Abstract

In 16 patients with recurrences of squamous cell cancer of the upper aerodigestive system a combination-chemotherapy was performed in three cycles. On the 1st day of each cycle 20 mg/m2 methotrexate and 15 mg bleomycin, on the 2nd day 60 mg/m2 cis-diamminedichloroplatinum and from day 3 until day 8 15 mg bleomycin was given daily. Only half the patients received all 3 planned cycles. The overall response rate for complete or partial remission (more than 50% tumor-shrinkage) was 37% (1 complete, 5 partial remissions). Median duration of remissions was 2.6 months (1-6 months). Life quality (modified Karnowsky Index) was improved in 5 patients, tumor pain could be reduced in 7 patients. The median survival time was 4.3 months. The results are compared to those of other authors.

• Authors: K Böheim, H Rauchegger
• Journal: Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 133 Issue 17 Pg. 413-9 (Sep 15 1983) ISSN: 0043-5341 [Print] Austria
• Vernacular Title: Welche Erwartungen dürfen in eine palliative Chemotherapie von Rezidivtumoren der oberen Luft- und Speisewege gesetzt werden?
• PMID: 6195829 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bleomycin
• Cisplatin
• Methotrexate

Topics

• Bleomycin (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy)
• Cisplatin (therapeutic use)
• Digestive System Neoplasms (drug therapy)
• Drug Therapy, Combination
• Humans
• Methotrexate (therapeutic use)
• Middle Aged
• Neoplasm Recurrence, Local
• Palliative Care
• Respiratory Tract Neoplasms (drug therapy)