Pulmonary veno-occlusive disease due to bleomycin therapy for lymphoma. Case reports.

Abstract

Two patients with lymphocytic lymphoma and bleomycin-induced pulmonary toxicity were shown at autopsy to have pulmonary venular alterations identical to pulmonary veno-occlusive disease (PVOD). While hepatic veno-occlusive disease due to alkylating agents has been reported, I am unaware of any report of PVOD related to bleomycin therapy.

• Authors: A G Rose
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 64 Issue 16 Pg. 636-8 (Oct 08 1983) ISSN: 0256-9574 [Print] South Africa
• PMID: 6194564 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bleomycin

Topics

• Adult
• Bleomycin (adverse effects)
• Constriction, Pathologic (chemically induced)
• Humans
• Lymphoma (drug therapy)
• Male
• Middle Aged
• Pulmonary Veins (drug effects, pathology)
• Thrombosis (chemically induced)
• Venules (pathology)