Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.

Abstract

Proliferation of lectin-treated mouse thymocytes induced by the tumor promoter, 12-0-tetradecanoyl-13-acetate, is markedly inhibited by cAMP analogues, prostaglandin E and methylisobutylxanthine. Proliferation induced by interleukin-2 is resistant to inhibition by these compounds. The tumor promoter induces interleukin-2 production in a subpopulation of lectin-treated thymocytes, and production of this lymphokine is inhibited by agents that increase cellular cAMP.

• Authors: A Novogrodsky, M Patya, A L Rubin, K H Stenzel
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 114 Issue 1 Pg. 93-8 (Jul 18 1983) ISSN: 0006-291X [Print] United States
• PMID: 6192817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-2
• Phorbols
• Prostaglandins E
• Theophylline
• Cyclic AMP
• Alprostadil
• Tetradecanoylphorbol Acetate
• 1-Methyl-3-isobutylxanthine

Topics

• 1-Methyl-3-isobutylxanthine (pharmacology)
• Alprostadil
• Animals
• Cyclic AMP (metabolism)
• Cytotoxicity, Immunologic (drug effects)
• Interleukin-2 (biosynthesis, physiology)
• Kinetics
• Lymphocytes (drug effects, immunology)
• Mice
• Mice, Inbred BALB C
• Phorbols (pharmacology)
• Prostaglandins E (pharmacology)
• Tetradecanoylphorbol Acetate (pharmacology)
• Theophylline (analogs & derivatives)
• Thymus Gland (immunology)