Adenomatoid tumor: immunohistological features suggesting a mesothelial origin.

Abstract

Four adenomatoid tumors of the epididymis were evaluated immunohistologically for the expression of intermediate filaments and endothelial cell markers, factor VIII-related antigen and binding of Ulex europaeus I-lectin (UEA I). Immunofluorescence microscopy showed a strong reaction with antikeratin but not with anti-vimentin antibodies, indicating that adenomatoid tumor cells contain epithelial but not mesenchymal type of intermediate filaments. No staining of tumor cells was seen with anti-FVIII-related antigen antibodies or with fluorochrome-coupled UEA I. The results support the mesothelial, non-endothelial origin of adenomatoid tumors.

• Authors: V P Lehto, M Miettinen, I Virtanen
• Journal: Virchows Archiv. B, Cell pathology including molecular pathology (Virchows Arch B Cell Pathol Incl Mol Pathol) Vol. 42 Issue 2 Pg. 153-9 ( 1983) ISSN: 0340-6075 [Print] Germany
• PMID: 6189284 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens
• Lectins
• von Willebrand Factor
• Keratins
• Factor VIII

Topics

• Adult
• Aged
• Antigens (analysis)
• Cytoskeleton
• Epididymis
• Factor VIII (analysis, immunology)
• Humans
• Keratins (immunology)
• Lectins (analysis)
• Male
• Middle Aged
• Teratoma (immunology)
• Testicular Neoplasms (immunology)
• von Willebrand Factor