[Sequentially alternating chemotherapy of non-seminomatous testicular tumors with adriamycin/cisplatin and bleomycin/vinblastine. Therapeutic success and failure with respect to histology and tumor stages].

Abstract

The value of sequential alternating chemotherapy was analyzed retrospectively in 180 patients with disseminated, non-seminomatous testicular cancer. Response rates of adriamycin/cisplatin--(combination A) and bleomycin/vinblastine (combination B)--combination chemotherapy were evaluated separately with respect to tumor histology and tumor stages. Tumor response was achieved in 151 of 180 patients (84%) who were evaluable for adriamycin/cisplatin chemotherapy. Out of those, 91 of 117 patients (78%) pretreated with combination B and 60 of 63 patients (95%) without prior chemotherapy responded. Irrespective of pretreatment tumor response was observed in 131 of 157 patients (84%) evaluable for treatment with bleomycin/vinblastine. Resistance to combination A was 2.5 fold higher in embryonal carcinomas (class II of Dixon and Moore) than in choriocarcinomas (class V). Bleomycin/vinblastine-therapy failed more frequently in choriocarcinomas as compared to other histological categories (22% vs. 14%). This report also includes an analysis of treatment failures in different tumor stages. Both regimens were more frequently ineffective in tumor stages with a large tumor burden (stages II C and IV D). Patterns of cross-resistance were evaluated for both regimens. Response to adriamycin/cisplatin occurred in 18/26 patients (69%), when combination B had failed, and response to bleomycin/vinblastine was achieved in 14/24 patients (58%) when adriamycin/cisplatin had failed. In patients not responding to either regimen the treatment failure was already recognized after the first chemotherapeutic course in 93% of these cases.

• Authors: J Schütte, K Bremer, N Niederle, B Schoetensack, C G Schmidt, S Seeber
• Journal: Onkologie (Onkologie) Vol. 6 Issue 1 Pg. 16-20 (Feb 1983) ISSN: 0378-584X [Print] Switzerland
• Vernacular Title: Sequentiell-alternierende Chemotherapie nicht-seminomatöser Hoden-tumoren mit Adriamycin/Cisplatin und Bleomycin/Vinblastin. Therapieansprechen und -versagen in Abhängigkeit von Histologie und Tumorstadium.
• PMID: 6189038 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Bleomycin
• Vinblastine
• Doxorubicin
• Cisplatin

Topics

• Antineoplastic Agents (administration & dosage)
• Bleomycin (administration & dosage)
• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Resistance
• Drug Therapy, Combination
• Humans
• Male
• Neoplasm Staging
• Retrospective Studies
• Testicular Neoplasms (drug therapy, pathology)
• Vinblastine (administration & dosage)