Abstract |
Eighteen patients with advanced Hodgkin's disease, refractory to combination chemotherapy with nitrogen mustard, vincristine, prednisone, and procarbazine (MOPP), were treated with vinblastine, doxorubicin ( Adriamycin), bleomycin, CCNU, and dacarbazine ( DTIC) (VABCD). Fifteen patients had Stage IV disease and 11 had systemic symptoms. Although hematologic toxicity was considerable, there was no drug related mortality. Eight patients achieved a complete remission (CR), and five are currently in a continuous CR of five, 24, 30, 34, and 36 months duration, respectively. An additional patient had a 30-month CR and relapsed with localized lymphadenopathy and is currently disease-free following involved-field radiotherapy 46 months from initiation of VABCD. This study suggests that long-term disease-free survival and potential cure can be achieved with VABCD in MOPP-refractory Hodgkin's disease.
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Authors | L H Einhorn, S D Williams, E E Stevens, W H Bond, L Chenoweth |
Journal | Cancer
(Cancer)
Vol. 51
Issue 8
Pg. 1348-52
(Apr 15 1983)
ISSN: 0008-543X [Print] United States |
PMID | 6186356
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Bleomycin
- Procarbazine
- Mechlorethamine
- Vincristine
- Vinblastine
- Lomustine
- Dacarbazine
- Doxorubicin
- Prednisone
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Topics |
- Adolescent
- Adult
- Agranulocytosis
(chemically induced)
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
- Bleomycin
(administration & dosage, adverse effects)
- Clinical Trials as Topic
- Dacarbazine
(administration & dosage, adverse effects)
- Doxorubicin
(administration & dosage, adverse effects)
- Drug Resistance
- Drug Therapy, Combination
- Female
- Hodgkin Disease
(drug therapy)
- Humans
- Lomustine
(administration & dosage, adverse effects)
- Male
- Mechlorethamine
(administration & dosage)
- Middle Aged
- Prednisone
(administration & dosage)
- Procarbazine
(administration & dosage)
- Prognosis
- Thrombocytopenia
(chemically induced)
- Vinblastine
(administration & dosage, adverse effects)
- Vincristine
(administration & dosage)
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