[Prevention of viral hepatitis B with specific gamma globulin. Results of 2 years' experience in a hemodialysis center].

Abstract

Prophylaxis with gamma globulins specific for virus hepatitis B was carried out at the Trieste Haemodialysis Centre from December 1979 to December 1981. Since no clear distinction could be drawn between HBsAg-positive dialysed subjects, all staff and patients at the Centre were regarded as constantly at risk for contagion, and hence in the post-exposure state. Those who refused prophylaxis were excluded, together with surface antigen carriers and subjects with antibodies. Specific gamma globulins (Uman-Big) were given at a dose of 0.06 cc/kg at intervals of 90-105 days, together with 0.02 cc/kg standard gamma globulins for conjectured protection against non-A and non-B hepatitis. No allergic reactions worthy of not were observed. Only one patient positivised of all those who underwent continuous prophylaxis. New carriers of HBsAg gradually decreased in number from 1976 to 1981, initially due to the adoption of disposable filters, subsequently owing to partial separation of Au-positives, and finally, in a significant manner, with the introduction of prophylaxis with specific gamma globulins.

• Authors: C Bevilacqua, F Dardi, P Gobbato, F Vidali, L Fayenz
• Journal: Minerva medica (Minerva Med) Vol. 73 Issue 44 Pg. 3123-9 (Nov 17 1982) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Profilassi dell'epatite virale B con gamma globuline specifiche. Risultati di due aunni di esperienza in un Centro di Emodialisi.
• PMID: 6183617 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis B Antibodies
• gamma-Globulins

Topics

• Hepatitis B (prevention & control)
• Hepatitis B Antibodies (administration & dosage)
• Humans
• Immunization Schedule
• Renal Dialysis (adverse effects)
• Risk
• gamma-Globulins (therapeutic use)