Studies of antinuclear antibodies in rheumatoid arthritis.

Abstract

Antinuclear antibodies (ANA) by the indirect immunofluorescence method and their immunospecificities were investigated in 60 patients with rheumatoid arthritis using HEp-2 cells as substrates. ANA were detected in 35% of the patients. The patterns of nuclear staining observed included: diffuse or patchy homogeneous (20%), speckled (8.3%), centromere (3.3%), nucleolar (1.6%) and in 1 patient a mixed pattern (1.6%). The presence of antihistone antibodies (20%) correlated with the presence of an homogeneous pattern on the HEp-2 cells.

• Authors: I Garcia-de la Torre, L Miranda-Mendez
• Journal: The Journal of rheumatology (J Rheumatol) 1982 Jul-Aug Vol. 9 Issue 4 Pg. 603-6 ISSN: 0315-162X [Print] Canada
• PMID: 6182293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• Epitopes
• Histones

Topics

• Adult
• Aged
• Antibodies, Antinuclear (analysis)
• Arthritis, Rheumatoid (diagnosis, immunology)
• Cell Nucleolus (immunology)
• Centromere (immunology)
• Epitopes (immunology)
• Female
• Fluorescent Antibody Technique
• Histones (immunology)
• Humans
• Male
• Middle Aged